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They include, but are not limited to, effects on the heart and cardiovascular system, the gastrointestinal tract, the respiratory tract, the eye, the liver, and the genitourinary system.
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Hydrochlorothiazide added significantly to the antihypertensive effect of bisoprolol in elderly hypertensive patients.
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However, in the Prospective Randomized Amlodipine Survival Evaluation (PRAISE) trial (presented at the 44th Annual Scientific Session of the ACC), the administration of amlodipine in patients with heart failure was not accompanied by an adverse effect on morbidity or mortality; rather, the study reported a favorable effect of amlodipine on the survival of patients with nonischemic dilated cardiomyopathy.
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Dose titration to a targeted blood glucose goal is achieved over several days with changes from the existing total daily insulin dose of no more than 2 to 6 USP Insulin Human Units a day; again, with consideration of body weight.
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Uric acid, serum potassium, glucose, and phosphorus increases associated with use of this drug were not of clinical importance and rarely resulted in discontinuation.
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